DNA mimicry by proteins as effective mechanism for regulation of activity of DNA-dependent enzymes |
| |
| Authors: | G B Zavilgelsky S M Rastorguev |
| |
| Institution: | (1) State Research Institute of Genetics and Selection of Industrial Microorganisms, 1-yi Dorozhnyi Proezd 1, 117545 Moscow, Russia |
| |
| Abstract: | Modern concepts on mechanisms of DNA-dependent enzyme regulation involving specific DNA-mimicking proteins are considered. There are proteins that share structural resemblance with DNA duplexes. These include inhibitors of type I restriction-modification enzymes (Ocr and ArdA), inhibitors of DNA gyrase MfpA and QnrABS, etc. We describe here structural features of these proteins and mechanisms responsible for their interaction with DNA-dependent enzymes and then discuss perspectives of use of DNA-mimicking proteins in analysis of replication, repair, recombination, mechanisms underlying resistance to antibiotics, and also fields of applied biotechnology. |
| |
| Keywords: | DNA-mimicry antirestriction drug resistance quinolone ArdA MfpA QnrABS Ocr |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
