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Effects of subinhibitory concentrations of nitroxoline on the surface properties of Escherichia coli |
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| Authors: | Latrache H Bourlioux P Karroua M Zahir H Hakkou A |
| Affiliation: | (1) Laboratoire de Microbiologie, Faculté de Pharamacie, Université Parix XI, 92 296 Chátenay-Malabry cedex, France;(2) Laboratoire de Cinétique et Catalyse, Faculté de Sciences, Université Mohamed 1er, Oujda, Maroc;(3) Laboratoire de Biochimie, Faculté de Sciences, Université Mohamed 1er, Oujda;(4) Laboratoire de Valorisation et Sécurité des produits. Alimentaires, Faculté des Sciences et Techniques, Beni Mellal, Maroc |
| Abstract: | Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenicEscherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+. The effect of NIQ on the cell surface was not related to the bacteriostatic effect of this agent. The increase in nitrogen and decrease in phosphate content in the cell surface was found in the presence of NIQ. NIQ did not inhibit the expression of fimbriae. |
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