aUCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK;bUCB S.A., R&D, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
Abstract:
We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure–activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule.