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Imidazopyridines as VLA-4 integrin antagonists |
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| Authors: | Phillips David J Davenport Richard J Demaude Thierry A Galleway Fiona P Jones Mark W Knerr Laurent Perry Benjamin G Ratcliffe Andrew J |
| Affiliation: | aUCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK;bUCB S.A., R&D, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium |
| Abstract: | We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure–activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. |
| Keywords: | VLA-4 Integrin Imidazopyridine Phenylalanine |
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