The genes for CD37, CD53, and R2, all members of a novel gene family,are located on different chromosomes |
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| Authors: | Kimmo I Virtaneva Pavla Angelisová Thomas Baumruker Václav Ho?ej?í Heli Nevanlinna Jim Schröder |
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| Institution: | (1) Department of Genetics, University of Helsinki, Arkadiankatu 7, SF-00100 Helsinki, Finland;(2) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Vídenská 1083, 14220 Praha 4, Czechoslovakia;(3) Department of Immunopharmacology, Sandoz Research Institute Ltd., Brunnestr. 59, A-1235 Vienna, Austria;(4) Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, SF-00290 Helsinki, Finland |
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| Abstract: | CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a sub-population of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12. |
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