Association of Y chromosome haplogroup I with HIV progression, and HAART outcome |
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Authors: | Efe Sezgin Joanne M Lind Sadeep Shrestha Sher Hendrickson James J Goedert Sharyne Donfield Gregory D Kirk John P Phair Jennifer L Troyer Stephen J O’Brien Michael W Smith |
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Institution: | Efe Sezgin, Joanne M. Lind, Sadeep Shrestha, Sher Hendrickson, James J. Goedert, Sharyne Donfield, Gregory D. Kirk, John P. Phair, Jennifer L. Troyer, Stephen J. O’Brien and Michael W. Smith |
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Abstract: | The host genetic basis of differential outcomes in HIV infection, progression, viral load set point and highly active retroviral
therapy (HAART) responses was examined for the common Y haplogroups in European Americans and African Americans. Accelerated
progression to acquired immune deficiency syndrome (AIDS) and related death in European Americans among Y chromosome haplogroup
I (Y-I) subjects was discovered. Additionally, Y-I haplogroup subjects on HAART took a longer time to HIV-1 viral suppression
and were more likely to fail HAART. Both the accelerated progression and longer time to viral suppression results observed
in haplogroup Y-I were significant after false-discovery-rate corrections. A higher frequency of AIDS-defining illnesses was
also observed in haplogroup Y-I. These effects were independent of the previously identified autosomal AIDS restriction genes.
When the Y-I haplogroup subjects were further subdivided into six I subhaplogroups, no one subhaplogroup accounted for the
effects on HIV progression, viral load or HAART response. Adjustment of the analyses for population stratification found significant
and concordant haplogroup Y-I results. The Y chromosome haplogroup analyses of HIV infection and progression in African Americans
were not significant. Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect
on AIDS progression and treatment responses in European Americans.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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