Microcalorimetry of biological macromolecules |
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| Authors: | Privalov Peter L Dragan Anatoly I |
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| Institution: | Johns Hopkins University, Baltimore, MD 21218, USA. privalov@jhu.edu |
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| Abstract: | The capabilities of contemporary differential scanning and isothermal titration microcalorimetry for studying the thermodynamics of protein unfolding/refolding and their association with partners, particularly target DNA duplexes, are considered. It is shown that the predenaturational changes of proteins must not be ignored in studying the thermodynamics of formation of their native structure and their complexes with partners, particularly their cognate DNA duplexes. |
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