Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins |
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| Authors: | Johan Nilsson Mats Grahn Anthony PH Wright |
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| Affiliation: | 1.School of Life Sciences, Södertörn University, SE-141 89 Huddinge, Sweden;2.Clinical Research Center, Novum Level 5, Department of Laboratory Medicine and Center for Biosciences, Karolinska Institutet, SE-141 86 Huddinge, Sweden |
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| Abstract: | Background Understanding the adaptive changes that alter the function of proteins during evolution is an important question for biology and medicine. The increasing number of completely sequenced genomes from closely related organisms, as well as individuals within species, facilitates systematic detection of recent selection events by means of comparative genomics. |
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