Recombination between chloroplast DNAs does not occur in sexual crosses of Oenothera |
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| Authors: | Abdul M. Chaudhury and Gerald R. Smith |
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| Affiliation: | (1) Fred Hutchinson Cancer Research Center, 1124 Columbia Street, 98104 Seattle, WA, USA;(2) Present address: National Institute of Environmental Health Sciences, P.O. Box 12233, 27709 Research Triangle Park, NC, USA |
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| Abstract: | Summary Induction of the SOS genes is required for efficient repair of damaged DNA in Escherichia coli. SOS induction by nalidixic acid or oxolinic acid, two inhibitors of DNA gyrase, requires the RecBC enzyme of E. coli. We report here that the nuclease activity of RecBC enzyme is not needed for SOS induction by these agents. We suggest that the unwinding activity of RecBC enzyme produces single-stranded DNA which activates the RecA protein to stimulate LexA repressor cleavage and SOS induction. |
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