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The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress |
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| Authors: | Yakhine-Diop Sokhna M S Rodríguez-Arribas Mario Canales-Cortés Saray Martínez-Chacón Guadalupe Uribe-Carretero Elisabet Blanco-Benítez Mercedes Duque-González Gema Paredes-Barquero Marta Alegre-Cortés Eva Climent Vicente Aiastui Ana López de Munain Adolfo Bravo-San Pedro José M Niso-Santano Mireia Fuentes José M González-Polo Rosa A |
| Institution: | 1.Departamento de Bioquímica Y Biología Molecular Y Genética, Facultad de Enfermería Y Terapia Ocupacional, Universidad de Extremadura, Cáceres, Spain ;2.Centro de Investigación Biomédica en Red de Enfermedades (CIBERNED), Madrid, Spain ;3.Instituto de Investigación Biosanitaria de Extremadura (INUBE), Cáceres, Spain ;4.Departamento de Anatomía Y Embriología Humana, Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain ;5.Cell Culture Platform, Donostia University Hospital, San Sebastián, Spain ;6.Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, San Sebastián, Spain ;7.Department of Neurology, Donostia University Hospital, San Sebastian, Spain ;8.Ilundain Foundation, San Sebastian, Spain ;9.Department of Neurosciences, University of the Basque Country UPV-EHU, San Sebastián, Spain ;10.Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain ; |
| Abstract: | Cell Biology and Toxicology - Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised... |
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