膝关节内干细胞/祖细胞在软骨再生中作用研究进展

关节软骨(AC)由于缺乏血管、神经和淋巴,一旦损伤无法自我修复。虽然以外源性细胞为基础的治疗策略在一定程度上能够再生关节软骨,但仍然存在手术间隔长、供体有限、细胞体外培养易去分化和病原体传播等风险。成人膝关节存在许多类型干细胞/祖细胞(SCPCs),当软骨损伤时,就会被动员,迁移到损伤部位,参与再生修复。因此,基于趋化内源性SCPCs到损伤部位的AC原位再生修复策略,充分利用机体自我修复潜力,同时避免了外源性细胞策略的缺点,已经成为研究的热点。本综述主要介绍膝关节内SCPCs类型、迁移路径以及其在软骨损伤修复中的作用。重点介绍内源性AC再生修复策略的研究现状,以期吸引更多的研究人员参与这一有前景的研究领域。

Progress of native joint-resident stem cells/progenitor cells in cartilage regeneration

Articular cartilage(AC)cannot repair itself due to the lack of blood vessels,nerves and lymph,To some extent,exogenous cell-based treatment strategies can regenerate articular cartilage,however,there were some risks such as long surgical interval,limited donor availability,easy cell dedifferentiation in vitro and pathogen transmission.When cartilage is damaged,many kinds of stem cells/progenitor cells(SCPCs)in adult knee joints will be mobilized and migrated to damaged area and participate in regeneration repair.Therefore,based on recruitment endogenous SCPCs,the in-situ AC regeneration strategy has become a research hotspot,which fully utilizes the body's self-repair potential and avoids the disadvantages of exogenous cell strategy.The characteristics and migration pathway of different SCPCs in the knee joint and its role in the repair of cartilage injury were introduced.At the same time,progress of endogenous AC regeneration and repair strategies were mainly focused,in order to attract more researchers to participate in this promising research field.