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Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes |
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| Authors: | Wijaya Lukas S Rau Carina Braun Theresa S Marangoz Serif Spegg Vincent Vlasveld Matthijs Albrecht Wiebke Brecklinghaus Tim Kamp Hennicke Beltman Joost B Hengstler Jan G van de Water Bob Leist Marcel Schildknecht Stefan |
| Institution: | 1.Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300, RA, Leiden, The Netherlands ;2.In vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, P.O. Box M657, Universit?tsstr. 10, 78457, Konstanz, Germany ;3.Konstanz Research School Chemical Biology (KoRS-CB), Department of Chemistry, University of Konstanz, 78457, Konstanz, Germany ;4.Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany ;5.BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany ;6.Albstadt-Sigmaringen University, Faculty of Life Sciences, 72488, Sigmaringen, Germany ; |
| Abstract: | Cell Biology and Toxicology - Toxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to... |
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