Anti‐cancer therapy with TNFα and IFNγ: A comprehensive review |
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| Authors: | Jing Shen Zhangang Xiao Qijie Zhao Mingxing Li Xu Wu Lin Zhang Wei Hu Chi H Cho |
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| Institution: | 1. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China;2. School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China |
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| Abstract: | Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally found to be produced by inflammatory cells and play important roles in the immune system and surveillance of tumour growth. By activating distinct signalling pathways of nuclear factor‐κB (NF‐κB), mitogen‐activated protein kinase (MAPK), and JAK/STAT, TNFα and IFNγ were reported to effectively trigger cell death and perform powerful anti‐cancer effects. In this review, we will discuss the new advancements of TNFα and IFNγ in anti‐cancer therapy. |
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