Inhalation of endothelin receptor blockers in pulmonary hypertension |
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| Authors: | Leuchte Hanno H Meis Tobias El-Nounou Michal Michalek Jens Behr Jürgen |
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| Institution: | Division of Pulmonary Diseases, Department of Internal Medicine I, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany. Hanno.Leuchte@med.uni-muenchen.de |
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| Abstract: | Endothelin 1 (ET-1) is a potent pulmonary vasoconstrictor and mediator of lung diseases. Antagonism of the ET-1-mediated effects has become an important therapeutic approach. ET-1 (A and B) receptors are differentially distributed in the lung vasculature. Whereas the ET(A) receptors mainly mediate vasoconstriction, the endothelial ET(B) receptor seems to have vasodilative properties. We sought to determine if antagonism of ET receptors can be achieved by inhalation of specific blockers in a model of ET-1-mediated pulmonary hypertension. |
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