Stimulation of gastrin secretion from the perfused rat stomach by somatostatin antiserum |
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| Authors: | B Saffouri G Weir K Bitar G Makhlouf |
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| Institution: | Divisions of Gastroenterology and Endocrinology Medical College of Virginia Richmond, Virginia, 23298, USA |
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| Abstract: | The effect of a high capacity somatostatin antiserum on antral gastrin secretion was examined in an isolated vascularly perfused rat stomach preparation. Infusion of somatostatin antiserum diluted 1:1 and 1:9 with Krebs buffer solution produced significant increases in gastrin secretion throughout the period of infusion. Neither infusion of somatostatin antiserum diluted 1:99 nor infusion of control rabbit serum had any effect on gastrin secretion. The data indicate that antral somatostatin excercises a continous restraint on gastrin secretion in the basal state. |
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| Keywords: | Address Correspondence to: G M Makhlouf M D Ph D Box 711 Medical College of Virginia Richmond Virginia 23298 |
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