Variations among clinical isolates of Staphylococcus aureus to induce expression of E-selectin and ICAM-1 in human endothelial cells |
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Authors: | Strindhall Jan Lindgren Per Eric Löfgren Sture Kihlström Erik |
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Affiliation: | Department of Natural Science and Biomedicine, University College of Health Sciences, P.O. Box 1038, S-551 11, J?nk?ping, Sweden. jan.strindhall@hhj.hj.se |
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Abstract: | Eighteen clinical isolates of Staphylococcus aureus, nine methicillin-sensitive and nine methicillin-resistant, were investigated for their ability to induce expression of E-selectin and ICAM-1 in human endothelial cells. Upregulation of adhesion molecules varied between isolates; 17 isolates induced expression of E-selectin and 13 of ICAM-1. Some isolates induced a significant expression of E-selectin without stimulation of ICAM-1, whereas the opposite was not found. Bacterial viability was required for induction of the adhesion molecules. The kinetics of ICAM-1 expression in S. aureus-infected cells differed from those stimulated with interleukin-1beta (IL-1beta). On the other hand, expression of E-selectin was very similar in S. aureus-infected and IL-1beta-stimulated cells. There was no correlation between ability of S. aureus to induce expression of cell adhesion molecules, methicillin susceptibility, pulse field gel electrophoresis patterns, biochemical characteristics, phage typing and toxin production. |
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Keywords: | Human umbilical cord vein endothelial cell E-selectin ICAM-1 Staphylococcus aureus |
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