我院2010年度药物不良反应分析

目的分析药物不良反应(ADR)发生的特点与规律,促进临床合理用药。方法回顾性分析2010年1~12月我院上报的401份ADR报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果静脉给药较其他给药途径更易发生ADR(336例,占83.89%);抗感染药物引发ADR的比例最高(159例,占39.65%),其次为营养药、消化系统药物及抗肿瘤药物;头孢菌素类药物是引发ADR的主要抗菌药物(15种,28.85%),其次为青霉素类(10种,19.23%)。ADR主要累及皮肤及附件损害为主,其次涉及到消化系统以及神经系统损害。结论临床科室应重视ADR监测,减少ADR的发生,提高合理用药水平。

Analysis of ADR about the First Affiliated Hospital of Guangxi Medical University Hospital in 2010

Objective To analysis the essential characteristics and rules of adverse drug reactions （ADR）,in order to promote clinical rational drug use. Methods 401 ADR reports received between Jan to Dec 2010 in the hospi- tal were systematically analyzed with retrospective analysis, according to the age, sex, patient delivery methods, ADR types,involving drugs organ or system and clinical manifestation of statistics. Results Intravenous drug administrations were more likely to induce ADR（336 cases, 83.79 ~ ）. The greatest proportion of ADR was caused by antimicrobial agents （159 cases, 39.65~）, followed by agents for nutritional support, digestive system drugs and antineoplastic drugs. Cephalosporin drugs were the most common drug suspected causing ADR （15 types, 28.85%） ,followed by penicillin antibiotics （10 types, 19.23%）. Impairment of skin and its appendages like skin rash,itich were most commonly experienced of clinical manifestation of ADR, followed by impairment digestive sys- tems and nervous systems. Conclusion ADR monitoring and report should be strengthened in the clinic,advance prevention, screening and treatment ADR,in order to promote rational and safe use of medicines in the clinic.