13C-31P couplings in the study of conformational properties of some diastereomeric nucleoside-3'-thiophosphate derivatives |
| |
| Authors: | Gács-Baitz Eszter Sági Gyula Kajtár-Peredy Mária |
| |
| Institution: | Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary. egacs@chemres.hu |
| |
| Abstract: | Synthesis and stereochemical characterization of enantiomerically pure nucleoside-3'-phosphorothioate esters and salts are reported. Vicinal carbon phosphorus couplings reflect different predominance of the epsilon conformation in the isomeric (Rp and Sp) esters, while for the salts the epsilont conformation prevails in both stereoisomers. The influence of solvent and temperature on the conformational preferences is also described. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
