<Emphasis Type="SmallCaps">l</Emphasis>-Aspartate-immunoreactive neurons in the rat enteric nervous system |
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Authors: | Email author" target="_blank">Masato?NagahamaEmail author Ning?Ma Reiji?Semba |
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Institution: | (1) Department of Anatomy II, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-0001, Japan;(2) Aichi Human Service Center, Institute for Developmental Research, 713-8 Kamiya-cho, Kasugai, Aichi, 480-0392, Japan |
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Abstract: | l-Aspartate (l-Asp) is an excitatory neurotransmitter in the central nervous system. In the present study, we demonstrate, for the first time, the presence of l-Asp in a particular neuronal cell class in the enteric nervous system (ENS). Scattered l-Asp-immunoreactive neuronal cell bodies and nerve fibers were found extensively in both the myenteric and submucosal plexus throughout the small and large intestines. Many l-Asp-immunoreactive nerve fibers, which originated from intrinsic nerve cell bodies, were found in the ganglia and interconnecting nerve bundles. Electron microscopy revealed that l-Asp-immunoreactive terminals frequently formed synaptic contacts with intrinsic nerve cells, suggesting that some l-Asp-immunoreactive neurons might function as interneurons. These results suggest that l-Asp-immunoreactive neurons play a significant role within the ENS to control intestinal functions. The presence of enteric l-Asp-immunoreactive neurons provides strong support for the proposal that l-Asp is a neuromodulator in the rat ENS. |
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Keywords: | Enteric nervous system l-Aspartate" target="_blank">l-Aspartate d-aspartate (NMDA) receptor" target="_blank">N-Methyl-d-aspartate (NMDA) receptor Amino acid Immunohistochemistry Rat (Wistar adult male) |
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