The state of gametes and the type of maturation of follicular oocytes in rats neonatally androgenized by LH-RH-induced ovulation

The character of follicular oocyte maturation and the state of gametes in androgenized rats was studied after LH-RH stimulation. The induction of ovulation with LH-RH has been shown to increase the number of rats with nonovulatory follicules and reduce the number of oocytes maturing prior to the onset of metaphase II. After the induction of ovulation the rate of chromosomal aberrations became higher than in intact animals. Ovulated oocyte population was characterized by the increased number of degenerated gametes. This increase was paralleled by decreased incidence of chromosomal aberrations in ovulated cells.