Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils |
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| Authors: | Uings Iain Puxeddu Ilaria Temkin Vladislav Smith Susan J Fattah Dilniya Ray Keith P Levi-Schaffer Francesca |
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| Affiliation: | Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel. fls@cc.huji.ac.il. |
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| Abstract: | SUMMARY: BACKGROUND: TNF-alpha is an important mediator in allergy also for its effects on eosinophils. METHODS: The effect of dexamethasone on TNF-alpha induced eosinophils survival, degranulation (ECP), cytokines release (IL-8, GM-CSF) and adhesion to VCAM-1, ICAM-1 and IgG coated wells (EPO release) were evaluated. RESULTS: The drug inhibited IL-8 and GM-CSF production, but not viability, degranulation or adhesion in human peripheral blood eosinophils. CONCLUSION: These results indicate that part of the activity of glucocorticosteroids on eosinophils may be mediated by their ability to inhibit cytokine secretion that in turn is important for the perpetuation of the allergic inflammation. |
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