HAC stability in murine cells is influenced by nuclear localization and chromatin organization |
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| Authors: | Daniela Moralli David YL Chan Andrew Jefferson Emanuela V Volpi Zoia L Monaco |
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| Affiliation: | (1) Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK |
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| Abstract: | Background Human artificial chromosomes (HAC) are small functional extrachromosomal elements, which segregate correctly during each cell division. In human cells, they are mitotically stable, however when the HAC are transferred to murine cells they show an increased and variable rate of loss. In some cell lines the HAC are lost over a short period of time, while in others the HAC become stable without acquiring murine DNA. |
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