Frequency encoding of intracellular Ca2+ signals |
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Authors: | Grubelnik Vladimir Marhl Marko |
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Affiliation: | Department of Physics, Faculty of Education, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia. |
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Abstract: | In a very recent theoretical study, we showed that simple mitochondrial kinetics, originally proposed by Marhl et al., could be easily used as a plug-in element in other models describing intracellular Ca2+ dynamics. We analysed several previously published models and showed that mitochondria could indeed maintain the constant amplitude of intracellular Ca2+ oscillations very effectively. We also pointed out the importance of amplitude regulation for the frequency encoding of intracellular Ca2+ signals. This paper focuses on giving a more exhaustive demonstration of this phenomenon of frequency encoding for the model of Dupont et al. |
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