Dexamethasone and zinc in combination inhibit the anchorage-independent growth of S-91 Cloudman murine melanoma |
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| Authors: | K L Kreutzfeld K Y Lei M D Bregman F L Meyskens |
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| Affiliation: | 1. Department of Nutrition and Food Science University of Arizona, Tucson, Arizona 85721, USA;2. Department of Internal Medicine and the Cancer Center Arizona Health Science Center, University of Arizona, Tucson, Arizona 85724, USA |
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| Abstract: | Zinc inhibited the colony formation of Cloudman S-91 murine melanoma cells in a dose dependent manner with an ID50 of 3.4 ug/ml. Total inhibition of the melanoma colony-forming units occurred at a zinc concentration of 4.42 ug/ml. In the presence of dexamethasone the ID50 for zinc inhibition was reduced by 49% and total inhibition of anchorage-independent growth occurred at the achievable in vivo zinc concentration of 3.0 ug/ml. Dexamethasone and zinc in combination effected a greater than additive inhibition of the murine melanoma colony-forming units. Statistical evaluation of these results showed that zinc and dexamethasone interacted synergistically to inhibit the formation of murine melanoma colonies. |
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