Comparison of the performance of two mycobacteriophage D29-based protocols for fluoroquinolone susceptibility testing in Mycobacterium tuberculosis |
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| Institution: | 1. Undergraduate Research Organization, Dhaka, Bangladesh;2. Department of Public Health and Informatics, Jahangirnagar University, Dhaka, Bangladesh;3. Pabna Medical College, Hemayatpur, Pabna, Bangladesh;4. International Gaming Research Unit, Psychology Department, Nottingham Trent University, Nottingham, UK;5. Department of Child Health and the Child Health Research Institute, The University of Missouri School of Medicine, Columbia, MO 65201, USA;1. Department of Microbiology and Immunology, Soonchunhyang University, 8 Soonchuhyang 2-gil, Cheonan si 330-721, Republic of Korea;2. Bioresourses Regional Innovation Center, Soonchunhyang University, Asan, Republic of Korea;3. Department of Chemistry, Soonchunhyang University, 22 Soonchunhyang-ro, Sinchangmyeon, Asan, Chungcheonam 336-745, Republic of Korea;1. Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal;2. Global Health and Sustainable Development, University College London, London WC1N 1EH, UK;1. National Heart and Lung Institute, Imperial College, London, UK;1. Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW 2145, Australia;2. Department of Internal Medicine, Hepatobiliary Division, Dr Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia;3. Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;4. Egyptian Liver Research Institute and Hospital, Mansoura, Egypt |
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| Abstract: | We tested a mycobacteriophage D29-based method for fluoroquinolone susceptibility assessment in clinical isolates of Mycobacterium tuberculosis. The method was incapable of identifying susceptible strains as such, although a slightly different published protocol successfully identified resistant and susceptible strains. Thus, caution is necessary when choosing an “in-house” D29-based protocol for testing of drug resistance. |
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