Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes |
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Authors: | Peng Wu Gang Deng Xiyalatu Sai Huiming Guo Huanlei Huang Ping Zhu |
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Affiliation: | 1.Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China;2.The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China |
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Abstract: | Induced pluripotent stem cells (iPSCs) have the ability to differentiate into cardiomyocytes (CMs). They are not only widely used in cardiac pharmacology screening, human heart disease modeling, and cell transplantation-based treatments, but also the most promising source of CMs for experimental and clinical applications. However, their use is largely restricted by the immature phenotype of structure and function, which is similar to embryonic or fetal CMs and has certain differences from adult CMs. In order to overcome this critical issue, many studies have explored and revealed new strategies to induce the maturity of iPSC-CMs. Therefore, this article aims to review recent induction methods of mature iPSC-CMs, related mechanisms, and limitations. |
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Keywords: | cardiomyocytes induced pluripotent stem cells limitations maturation strategies |
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