Hydroxymethylation of the benzene ring. Microsomal hydroxymethylation of benzo(alpha)pyrene to 6-hydroxymethylbenzo(alpha)pyrene |
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Authors: | N H Sloane T K Davis |
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Institution: | Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163 U.S.A. |
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Abstract: | The formation of 6-hydroxymethylbenzo(α)pyrene from benzo(α)pyrene has been shown to be catalyzed by sonicates of rat liver microsomes. The biosynthetic pathway for the formation of the aryl hydroxymethyl groups appears to be a direct hydroxymethylation of the benzene ring and not involve 6-methylbenzo(α)pyrene as an intermediate, because the formation of 6-hydroxymethylbenzo(α)pyrene is not a cytochrome P-450-mediated reaction, whereas a model aryl side chain methyl group hydroxylation has been shown to be inhibited by cytochrome P-450 inhibitors. |
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