Access to the inaccessible sequence of cpn 60.1 (195-217) by temporary oxazolidine protection of selected amide bonds |
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Authors: | Keller M Miller A D |
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Institution: | Imperial College Genetic Therapies Centre, Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, UK. mike.keller@ic.ac.uk |
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Abstract: | The solid-phase peptide synthesis of a reportedly inaccessible peptide sequence of chaperonin 60.1 (195-219) is described using oxazolidine containing dipeptide building blocks ('pseudo-proline' dipeptide units). Two attempts at the synthesis of the chaperonin 60.1 sequence are outlined using one and two pseudo-proline units, respectively, and these results are compared with the outcome of an ordinary stepwise (double) coupling procedure. The only successful synthesis is that combining two pseudo-proline building blocks. |
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