A Comparison of the Structures of the Alpha:Beta and Alpha:Gamma Dimers of Mouse Salivary Androgen-Binding Protein (ABP) and Their Differential Steroid Bindin |
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Authors: | Robert C Karn Mark A Clements |
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Institution: | Department of Biological Sciences, Butler University, Indianapolis, Indiana 46208, USA. |
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Abstract: | Mouse salivary androgen-binding protein (ABP) isa family of dimeric proteins that may play a pheromonalrole in Mus musculus. The protein dimer consists of acommon alpha subunit disulfide-bonded to avariable (beta or gamma) subunit. Here wereport N-terminal sequences of the beta and gammasubunits, showing that they are very similar to eachother while being quite different from the alphasubunit.We demonstrate differential androgen binding bythe two dimers. Both bind dihydrotestosterone to aboutthe same extent but the alpha:beta dimer bindssignificantly more testosterone than the alpha:gammadimer. We discuss the possible significance ofthis diversity of androgen binding with respect to thepossibility that androgen binding is related to aputative pheromonal role for the protein. |
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Keywords: | SALIVARY ANDROGEN-BINDING PROTEIN STEROID BINDING DIMER STRUCTURE DIHYDROTESTOSTERONE TESTOSTERONE |
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