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5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors |
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| Authors: | Gentile Gabriella Merlo Giancarlo Pozzan Alfonso Bernasconi Giovanni Bax Benjamin Bamborough Paul Bridges Angela Carter Paul Neu Margarete Yao Gang Brough Caroline Cutler Geoffrey Coffin Aaron Belyanskaya Svetlana |
| Institution: | Department of Medicinal Chemistry, Neuroscience Centre of Excellence of Drug Discovery, GlaxoSmithKline, Via A Fleming 4, 37135 Verona, Italy. |
| Abstract: | 5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described. |
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