Towards unravelling the Igf2/H19 imprinted domain |
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Authors: | Stphane Viville M Azim Surani |
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Affiliation: | Stéphane Viville,M. Azim Surani |
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Abstract: | Genomic imprinting is an epigenetic marking process that confers parent-of-origin-dependent expression on certain genes. These imprinted genes are sometimes found in clusters, suggesting a possible involvement of higher order regulatory elements controlling expression and imprinting of genes organised in such clusters. In the distal chromosome 7 there are at least four imprinted genes: Mash2, Ins2, Igf2 and H19. Recent evidence(1) suggests that imprinting and expression of at least Igf2 and H19 may be mechanistically linked. |
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