MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1 |
| |
Authors: | Xiu-Feng Gong An-Lu Yu Jun Tang Chen-Long Wang Jian-Rong He Guo-Qiang Chen Qian Zhao Ming He Ci-Xiang Zhou |
| |
Affiliation: | 1. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025, China;2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences/Chinese Academy of Sciences & Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, China;3. Department of General Surgery, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China |
| |
Abstract: | MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630. |
| |
Keywords: | miR-630 Breast cancer BMI1 Apoptosis |
本文献已被 ScienceDirect 等数据库收录! |
|