The role of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AcGEPC) and palmitoyl-lysophosphatidate in the responses of human blood platelets to collagen and thrombin |
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Authors: | T.J. Hallam M.C. Scrutton R.B. Wallis |
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Affiliation: | 1. Department of Biochemistry, King''s College, Strand, London WC2R 2LS, England;2. Research Centre, Ciba-Geigy Pharmaceuticals Division, Wimblehurst Road, Horsham, West Sussex RH12 4AB, England |
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Abstract: | Desensitisation of human blood platelets to the effects of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (1-O-alkylAcGEPC) and palmityl-lysophosphatidate by pre-incubation with these agonists has no effect on the aggregatory or secretory responses to collagen but causes 30–40% inhibition of these responses to thrombin in aspirin-treated platelets. The effects of 1-O-alkylAcGEPC and palmitoyl-lysophosphatidate are not additive. The results are not consistent with the proposal that 1-O-alkylAcGEPC or lysophosphatidate are the mediators for the responses to collagen observed when prostaglandinendo-peroxide synthesis is prevented, although they may play some role in the responses to thrombin under these conditions. |
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Keywords: | Present address: Physiological Laboratory Downing Street Cambridge CB2 3EG England |
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