Purinoceptors on Neuroglia |
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| Authors: | Alexei Verkhratsky Oleg A Krishtal Geoffrey Burnstock |
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| Institution: | (1) School of Biological Sciences, The University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK;(2) Institute of Experimental Medicine, ASCR, Videnska 1083, Prague, 142 20, Czech Republic;(3) Bogomoletz Institute of Physiology, Bogomoletz Str. 4, Kiev, Ukraine;(4) Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK |
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| Abstract: | Purinergic transmission is one of the most ancient and widespread extracellular signalling systems. In the brain, purinergic
signalling plays a unique role in integrating neuronal and glial cellular circuits, as virtually every type of glial cell
possesses receptors to purines and pyrimidines. These receptors, represented by metabotropic P1 adenosine receptors, metabotropic
P2Y purinoceptors and ionotropic P2X purinoceptors, control numerous physiological functions of glial cells and are intimately
involved in virtually every form of neuropathology. In this essay, we provide an in depth overview of purinoceptor distribution
in two types of CNS glia—in astrocytes and oligodendrocytes—and discuss their physiological and pathophysiological roles.
An erratum to this article can be found at |
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| Keywords: | ATP Adenosine P1 receptors P2Y receptors P2X receptors Astrocytes Oligodendrocytes |
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