Monoclonal antibodies against the human lymphocyte differentiation antigen CD 76 bind to gangliosides. |
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| Authors: | B Kniep P F Mühlradt B D?rken G Moldenhauer R Vilella R Schwartz-Albiez |
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| Institution: | GBF-Institute for Biotechnological Research, Braunschweig, FRG. |
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| Abstract: | Two monoclonal antibodies, HD 66 and CRIS-4, by which the new CD 76 B-cell-associated cluster was defined, bound to several gangliosides (sialic acid containing glycolipids) of different polarity. One of the gangliosides recognized by HD 66 could be identified as NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc-beta 1-1'Cer. This antigen was enzymatically synthesized. Sialidase treatment of the ganglioside antigens abolished binding of HD 66 and CRIS-4. |
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