CHALONE CONTROL OF MITOTIC ACTIVITY IN SEBACEOUS GLANDS |
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| Authors: | W S Bullough Edna B Laurence |
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| Institution: | Mitosis Research Laboratory, Birkbeck College, University of London |
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| Abstract: | Extracts of skin with sebaceous glands contain a substance which inhibits mitotic activity in sebaceous glands both in vivo and in vitro. This substance is neither the epidermal chalone nor the melanocyte chalone, both of which are also present in skin extracts. However, it resembles these other chalones in that it is water soluble, is precipitated by ethanol, is activated by the two stress hormones adrenalin and hydrocortisone, and is not species specific. It is present within the sebaceous glands, and it is evidently a sebaceous gland chalone. |
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