Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies |
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| Authors: | Khashayar Afshari Nazgol-Sadat Haddadi Arvin Haj-Mirzaian Mohammad Hosein Farzaei Mohammad Mojtaba Rohani Freshteh Akramian Rozita Naseri Antoni Sureda Negar Ghanaatian Amir Hossein Abdolghaffari |
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| Institution: | 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran;4. Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain
CIBEROBN (Physiopathology of Obesity and Nutrition, CB12/03/30038), Instituto de Salud Carlos III, Madrid, Spain |
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| Abstract: | Flavonoids comprise a group of natural polyphenols consisting of more than 5,000 subtypes mostly existing in fruits and vegetables. Flavonoids consumption could potentially attenuate the incidence and recurrence risk of colorectal cancers through their antiperoxidative, antioxidant, and anti-inflammatory effects. In addition, these compounds regulate the mitochondrial function, balance the bacterial flora and promote the apoptosis process in cancerous cells. However, some previous data failed to show the effectiveness of flavonoids in reducing the risk of colorectal cancer. In this study, we have reviewed the efficacy of different flavonoids subtypes on the risk of colon cancer and molecular mechanisms involved in this process in both clinical and animal studies. In addition, we tried to elucidate the potential synergy between these compounds and current colorectal cancer treatments. |
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| Keywords: | anti-inflammatory antioxidant colorectal cancer flavonoids supplement |
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