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miR-192/215-5p act as tumor suppressors and link Crohn's disease and colorectal cancer by targeting common metabolic pathways: An integrated informatics analysis and experimental study
Authors:Hu Zhao  Junqiu Chen  Jin Chen  Xuhui Kong  Hehuan Zhu  Yongping Zhang  Huiyue Dong  Jie Wang  Qun Ren  Qinghua Wang  Shushang Chen  Zhen Deng  Zhan Chen  Qiang Cui  Junqiong Zheng  Jun Lu  Shuiliang Wang  Jianming Tan
Institution:1. Department of Urology, Fujian Provincial Key Laboratory of Transplant Biology, 900 Hospital of the Joint Logistics Team, Xiamen University, Fuzhou, Fujian, China;2. Department of Urology, Fujian Provincial Key Laboratory of Transplant Biology, 900 Hospital of the Joint Logistics Team, Xiamen University, Fuzhou, Fujian, China

Hu Zhao, Junqiu Chen, Jin Chen, and Xuhui Kong contributed equally to this study.;3. Department of Neuro-oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas;4. Department of Oncology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan, Fujian, China

Abstract:MicroRNAs have emerged as key regulators involved in a variety of biological processes. Previous studies have demonstrated that miR-192/215 participated in progression of Crohn's disease and colorectal cancer. However, their concrete relationships and regulation networks in diseases remain unclear. Here, we used bioinformatics methods to expound miR-192/215-5p macrocontrol regulatory networks shared by two diseases. For data mining and figure generation, several miRNA prediction tools, Human miRNA tissue atlas, FunRich, miRcancer, MalaCards, STRING, GEPIA, cBioPortal, GEO databases, Pathvisio, Graphpad Prism 6 software, etc . are extensively applied. miR-192/215-5p were specially distributed in colon tissues and enriched biological pathways were closely associated with human cancers. Emerging role of miR-192/215-5p and their common pathways in Crohn's disease and colorectal cancer was also analyzed. Based on results derived from multiple approaches, we identified the biological functions of miR-192/215-5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways.
Keywords:bioinformatics  colorectal cancer  Crohn's disease  microRNA (miR)-192/215-5p
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