首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Association between TL1A gene polymorphisms and systemic lupus erythematosus in a Chinese Han population
Authors:Wang-Dong Xu  Lu Fu  Xiao-Yan Liu  Jia-Min Wang  Zhi-Chao Yuan  Lin-Chong Su  An-Fang Huang
Institution:1. Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, China;2. Laboratory Animal Center, Southwest Medical University, Luzhou, China;3. Department of Rheumatology and Immunology, Hubei Minzu University, Enshi, China;4. Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, China
Abstract:Our previous studies showed elevated tumor necrosis factor-like ligand 1 aberrance (TL1A) expression in systemic lupus erythematosus (SLE). However, TL1A polymorphisms with SLE susceptibility remain to be elucidated. In addition, we made meta-analysis to evaluate the relationship of TL1A polymorphisms and autoimmune diseases owing to inconsistent results. The present research was carried out by 404 SLE, 150 primary Sjogren's syndrome (pSS) patients, and 574 healthy individuals. Three TL1A polymorphisms (rs3810936, rs6478109, rs7848647) were genotyped using TaqMan genotyping assay. Then, the meta-analysis was performed by collecting the present case-control study and previously published research. Results showed that genotypes of rs3810936, rs7848647 were different between SLE patients and healthy controls, whereas no significant association was observed in the three polymorphisms and pSS patients. Genotypes distribution of rs6478109, rs7848647 were strongly related to lupus nephritis within SLE (p = 0.004, p = 0.011), respectively. Moreover, combined meta-analysis consisted of ten comparative research involving 4,305 patients and 5,600 controls. An association between autoimmune diseases and rs6478109 polymorphism was found. Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
Keywords:lupus  meta-analysis  single-nucleotide polymorphism  susceptibility  TL1A
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号