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Autophagy and senescence: A new insight in selected human diseases |
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| Authors: | Peramaiyan Rajendran Abdullah M Alzahrani Hamza N Hanieh Sekar Ashok Kumar Rebai Ben Ammar Thamaraiselavan Rengarajan Mohammed A Alhoot |
| Institution: | 1. Department of Biological Sciences, College of Science, King Faisal University, Hofouf, Saudi Arabia;2. Department of Biological Sciences, College of Science, King Faisal University, Hofouf, Saudi Arabia
Peramaiyan Rajendran and Abdullah M Alzahrani contributed equally to this work.;3. Department of Biological Sciences, College of Science, Al-Hussein Bin Talal University, Ma'an, Jordan Department of Medical Analysis, Aisha Bint Al Hussein College for Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan;4. Faculty of Technology, Center of Biotechnology, Anna University, Chennai, India;5. Department of Biological Sciences, College of Science, King Faisal University, Hofouf, Saudi Arabia Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology, Hammam-Lif, Tunisia;6. Scigen Research & Innovation, Periyar Technology Business Incubator, Thanjavur, India;7. Department of Medical Microbiology Unit, International Medical School (IMS), Management & Science University (MSU), Shah Alam, Malaysia |
| Abstract: | Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known for its disruptive effect on human diseases, and it is currently proposed to have a direct effect on triggering senescence and quiescence. However, it is yet to be proven whether autophagy has a positive or negative impact on senescence. It is known that elevated levels of autophagy induce cell death, whereas inadequate autophagy can trigger cellular senescence. Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer. Therefore, this review aims to highlight the relevance of senescence and autophagy in selected human ailments through a summary of recent findings on the connection and effects of autophagy and senescence in these diseases. |
| Keywords: | arthritis autophagy cancer cardiac diseases renal diseases senescence |