Emerging role of zinc finger protein A20 as a suppressor of hepatocellular carcinoma |
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Authors: | Peng Sheng Yi Yan Shu Wang Xiu Bi Xiao Bo Zheng Wan Jing Feng Lin Ye He Jian Shui Li |
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Institution: | 1. Department of Hepato-biliary-pancrease and Center of Severe Acute Pancreatitis of Northeast Sichuan, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China;2. Department of Liver Surgery and Transplantation, Affiliated Hospital of Sichuan University, P. R. China |
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Abstract: | Hepatocellular carcinoma (HCC), the third leading cause of cancer-associated mortality worldwide, is a major public health problem. Zinc finger protein A20 (A20), an acute phase response gene, is a potent inhibitor of NF-κB signaling. A20 serves a critical role in liver protection, including limiting inflammation following hepatic injury, stimulating hepatocyte growth, and preventing hepatic ischemia-reperfusion injury. A20 is also involved in different processes, including tumorigenesis, progression, and metastasis through multiple mechanisms. Accumulated studies have reported the clinical implications and biological relevance of A20 in the development and progression of HCC. The underlying mechanisms of A20 in HCC include inhibition of epithelial–mesenchymal transition, protein tyrosine kinase 2 activation and Rac family GTPase 1 activity. Combining liver protection with tumor inhibition is a unique advantage of A20, which has the potential to be a novel treatment for promoting liver regeneration following liver resection in patients with HCC with liver cirrhosis. This review discusses the hepato-protective effect of A20 on hepatocytes and its potential role in cancer development, particularly its suppressor effect on HCC. |
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Keywords: | hepatectomy hepatocellular carcinoma liver regeneration suppressor zinc finger protein A20 |
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