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Evaluation of cytokeratin 19 as a prognostic tumoral and metastatic marker with focus on improved detection methods |
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| Authors: | Masoumeh Mehrpouya Zeinab Pourhashem Najmeh Yardehnavi Morteza Oladnabi |
| Affiliation: | 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran Masoumeh Mehrpouya and Zeinab Pourhashem contributed equally to this work.;2. Student Research Committee, Pasteur institute of Iran, Tehran, Iran Masoumeh Mehrpouya and Zeinab Pourhashem contributed equally to this work.;3. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran |
| Abstract: | In the last few years, there has been a growing interest in Cytokeratin 19 (CK19) studies in the cancer research field. CK19 belongs to the Type I CKs, serves as a useful research tool in prognosis, diagnosis, and management of the tumors. In this paper, we dissect the metastatic potential of CK19, its relation with cancer stem cells and retinal epithelial cells behavior, its application as a tumor marker and its role among 30 cancers such as thyroid, thoracic, lung, pancreatic, cervical, colorectal, and so forth. CK19 expressed in several cancer types because of its metastatic potential. This paper also presents modified detection methods of CK19 in disseminated tumor cells. |
| Keywords: | biomarker Cytokeratin 19 disseminated tumor cells neoplasm diagnosis neoplasm prognosis |