LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR-377-3p |
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| Authors: | Chengmin Shi Tonglei Liu Junlin Chi Huayou Luo Zhizhong Wu Binghong Xiong Shuang Liu Yujian Zeng |
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| Institution: | 1. Department of Gastrointestinal Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, China
Chengmin Shi, Tonglei Liu, and Junlin Chi contributed equally to this study.;2. Department of Gastrointestinal Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, China;3. Department of Ultrasound, First Affiliated Hospital of Kunming Medical University, Kunming, China |
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| Abstract: | Up to date, the mechanism of gastric cancer (GC) development is poorly understood. This study was to demonstrate the effects of LINC00339 on GC progression. Here, we found that LINC00339 was overexpressed expressed in GC tissues and predicted poor outcome. By CCK8, colony formation and Transwell assays, we showed LINC00339 knockdown suppressed GC cell proliferation, migration, and invasion in vitro. Flow cytometry analysis (FACS) indicated that LINC00339 knockdown induced tumor cell apoptosis. Besides, we utilized the xenograft assay and found that LINC00339 depletion led to decreased tumor growth in vivo. Mechanistically, miR-377-3p was found to be inhibited by LINC00339. And LINC00339 suppressed miR-377-3p to upregulate DCP1A, which consequently promoted GC progression. In conclusion, LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR-377-3p. |
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| Keywords: | DCP1A gastric cancer LINC00339 miR-377-3p progression |
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