Targeting IL-34 in inflammatory autoimmune diseases |
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Authors: | Wang-Dong Xu An-Fang Huang Lu Fu Xiao-Yan Liu Lin-Chong Su |
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Affiliation: | 1. Department of Evidence-Based Medicine, Southwest Medical University, luzhou, China;2. Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, China;3. Laboratory Animal Center, Southwest Medical University, Luzhou, China;4. Department of Rheumatology and Immunology, Minda Hospital of Hubei Minzu University, Enshi, China |
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Abstract: | Interleukin-34 (IL-34) shares a common receptor with macrophage colony-stimulating factor (M-CSF), and can bind to CSF-1R, induces lymphocytes differentiation, proliferation, and regulates the synthesis of inflammatory components. Recent findings reported aberrant expression of IL-34 in several autoimmune disorders, such as lupus, arthritis, systemic sclerosis, inflammatory bowel diseases. The functional analysis further demonstrated that IL-34 may perform significantly in these inflammatory autoimmune disorders. IL-34 might consider as a biomarker for these diseases. I hope this collection of the findings in this review will improve knowledge of the role of IL-34, and targeting IL-34 may give the potential for these autoimmune diseases. |
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Keywords: | autoimmune cytokine IL-34 immune cell |
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