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LncRNA LINC01857 promotes growth,migration, and invasion of glioma by modulating miR-1281/TRIM65 axis |
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| Authors: | Guozhang Hu Naijie Liu Han Wang Yue Wang Zhigang Guo |
| Institution: | 1. Department of First-Aid Medicine, China-Japan Union Hospital of Jilin University, Changchun, China
Guozhang Hu and Naijie Liu 2. contributed equally to this study.;3. Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China Guozhang Hu and Naijie Liu 4. Department of Clinical Laboratory, Changchun Chinese Medicine University Affiliated Hospital, Changchun, China;5. Department of Pharmacology and Toxicology, Wright State University, Fairborn, Ohio;6. Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China |
| Abstract: | The great importance of long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually. LncRNA LINC01857 is a novel lncRNA and has been reported to promote breast cancer progression. However, the biological roles of LINC01857 in glioma are not explored. In the present research, LINC01857 levels were found to be upregulated in glioma. In addition, LINC01857 expression is negatively correlated with survival rate in glioma patients. Functional investigation revealed that LINC01857 downregulation impaired glioma proliferation and invasiveness. Furthermore, LINC01857 knockdown led to repressed growth of glioma in vivo. We found that LINC01857 could be a sponge for miR-1281 and inhibits its level to upregulate TRIM65 expression. What's more, we showed that miR-1281 mimics also attenuated tumor cell proliferation, migration, and invasion. And rescue assays demonstrated that LINC01857 promotes glioma progression through modulating miR-1281/TRIM65 pathway. Collectively, this study first demonstrated that a novel LINC01857/miR-1281/TRIM65 signaling regulates glioma progression. |
| Keywords: | glioma LINC01857 long noncoding RNAs migration proliferation |