Human BF*F-subtypes: segregation analysis with inclusion of MHC haplotypes |
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| Authors: | G. Geserick G. Mauff I. Siemens H. Waltz Antonia Mayer K. Bender M. Rose S. Goldmann Martina Brenden Helga Schröder |
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| Affiliation: | (1) Institut für Gerichtliche Medizin der Humboldt-Universität, Hannoversche Strasse 6, DDR-1040 Berlin, German Democratic Republic;(2) Hygiene-Institut der Universität, Goldenfelsstrasse 21, D-5000 Köln, Federal Republic of Germany;(3) Institut für Humangenetik und Anthropologie der Universität, Albertstrasse 11, D-7800 Freiburg i. Br., Federal Republic of Germany;(4) Arbeitsbereich Transplantationsimmunologie, DRK Blutspendezentrale, Heidenheimerstrasse 80, D-7900 Ulm, Federal Republic of Germany;(5) Abteilung für Transfusionsmedizin der Universität, Heidenheimerstrasse 80, D-7900 Ulm, Federal Republic of Germany |
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| Abstract: | Summary The segregation of factor B(BF)F subtypes was analyzed in conjunction with other MHC markers in 15 families with 89 offspring. Informative data for BF F subtypes were obtained from 11 families, 6 of them with known recombinant individuals for the HLA-B/DR/GLO region. The subtypes did not contribute further to the localization of the cross-overs, but followed the known segregation of conventional BF allotypes. In 2 families of one kinship, the recognition of heterozygous BF*FAFB individuals could be established following the inclusion of three generations. The rarer of the two BF F subtype alleles, BF*FA, is positively associated with the HLA haplotypes BW62, CW3, C4A*3 and A29, CWX, B44, C4A*3, B*1, DR7. BF F subtypes are regarded as a very useful additional tool for studies of MHC organization and disease association. |
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