Nuclear division,nuclear distribution and cytokinesis in filamentous fungi |
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Authors: | Michael Plamann |
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Institution: | 1. Department of Biology, Texas A & M University, 77843-3258, College Station, TX, USA
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Abstract: | Nuclear division, nuclear distribution and cytokinesis are fundamental processes of all eukaryotic organisms, and filamentous
fungi, specificallyAspergillus nidulans andNeurospora crassa, have provided sophisticated genetic systems for identification of the genes required for these processes. Mutational analyses
have led to identification of novel proteins that have subsequently been found to be conserved components required for nuclear-specific
functions. Formation of the mitotic spindle inA. nidulans has been shown to be dependent onγ-tubulin, a central element of all microtubule organizing centres, and two kinesin-related proteins. Analysis ofA. nidulans mitotic mutants has led to identification of two important cell-cycle regulators, NIMA and BIME. The NIMA kinase is required
for entry into mitosis, and BIME has recently been identified as a subunit of an anaphase-promoting complex that targets cyclins
for proteolysis. The microtubule-associated motor protein cytoplasmic dynein has been discovered in bothA. nidulans andN. crassa, and it has been proposed that it provides motive force for the distribution of nuclei within hyphae. Future studies of nucleus-specific
processes in filamentous fungi are likely not only to identify additional novel structural and regulatory proteins, but also
lead to an understanding of how the processes of nuclear division, nuclear distribution and septation are altered to meet
the developmental needs of the organism. |
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Keywords: | Nuclear division nuclear distribution septation |
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