Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist |
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Authors: | Schann Stephan Menet Christel Arvault Paul Mercier Géraldine Frauli Mélanie Mayer Stanislas Hubert Nadia Triballeau Nicolas Bertrand Hugues-Olivier Acher Francine Neuville Pascal |
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Affiliation: | Faust Pharmaceuticals, BIOPARC, Boulevard Sebastien Brant, 67400 Illkirch, France. sschann@faustpharma.com |
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Abstract: | A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach. Amongst 65 molecules tested on mGlu4, mGlu6 and mGlu8 subtypes, (2S,4S)-4-amino-1-[(E)-3-carboxyacryloyl]pyrrolidine-2,4-dicarboxylic acid (8a06-FP0429) has been shown to be a full mGlu4 agonist and a partial mGlu8 agonist. In addition, 8a06 was shown to be selective versus group I and II mGlu subtypes. A possible explanation for this efficacy difference is proposed by docking experiment performed with molecular model of the receptor. |
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