Statistical analysis of the distribution of the antibody levels to Mycobacterium bovis antigenes for bovine tuberculosis diagnostics |
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| Authors: | T. A. Redchuk N. V. Korotkevich A. A. Kaberniuk E. S. Oliinyk A. Yu. Labyntsev S. I. Romaniuk D. V. Kolibo V. A. Busol S. V. Komisarenko |
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| Affiliation: | 1. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
2. National University of Bioresources and Nature Management of Ukraine, Kiev, Ukraine
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| Abstract: | The antibody responses to the recombinant analogs of Mycobacterium bovis antigens rMPB63 and rMPB83, as well as to tuberculin PPD, were determined in 96 bovine blood serum specimens. A statistical approach based on the approximation with multiple Gaussian curves with Levenberg-Marquardt algorithm was proposed for analysis of the distribution of antibody levels to the studied antigens. The results demonstrate that the recombinant MPB63 and MPB83 antigens along with the traditionally used PPD are appropriate for designing the test kits for diagnosing bovine tuberculosis at a herd level. |
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