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Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) |
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| Authors: | Kim Soong-Hoon Pudzianowski Andrew T Leavitt Kenneth J Barbosa Joseph McDonnell Patricia A Metzler William J Rankin Bruce M Liu Richard Vaccaro Wayne Pitts William |
| Institution: | Bristol Myers Squibb Co., Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08560, USA. soonghoon.kim@bms.com |
| Abstract: | Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13. |
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