Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note |
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Authors: | Hamid A Merchant Harris M Shoaib Jaweria Tazeen Rabia I Yousuf |
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Institution: | (1) Faculty of Pharmacy, University Road, 75270 Karachi, Pakistan |
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Abstract: | Summary and Conclusions Decreasing the dose frequency of cefpodoxime proxetil increases patient compliance; patients prefer to take the drug once
daily. It also improves the rate of bacterial killing and hastens the cure from the indications, and therefore increases compliance.
The hydrophilic matrix of HPMC controlled the cefpodoxime proxetil release effectively for 24 hours; hence, the formulation
can be considered as a once-daily sustained-release tablet of cefpodoxime proxetil. The formulation showed acceptable pharmacotechnical
properties and assay requirements. In vitro dissolution studies indicated a sustained-release pattern throughout 24 hours
of the study that was comparable to the theoretical release profile. Drug release kinetics indicated that drug release was
best explained by Higuchi’s equation, as these plots showed the highest linearity (r
2=0.9734), but a close relationship was also noted with zero-order kinetics (r
2=0.9708). Korsmeyer’s plots indicated ann value of 0.57, which was indicative of an anomalous diffusion mechanism or diffusion coupled with erosion; hence, the drug
release was controlled by more than one process. Hixson-Crowell plots indicated a change in surface area and diameter of the
tablets with the progressive dissolution of the matrix as a function of time.
Published: September 22, 2006 |
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Keywords: | Cefpodoxime proxetil hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets in vitro sustained drug release once-daily tablet Cefpo SR |
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